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.select2-dropdown--below{border-top:none}.select2-container--classic .select2-results__option[role=group]{padding:0}.select2-container--classic .select2-results__option[aria-disabled=true]{color:grey}.select2-container--classic .select2-results__option--highlighted[aria-selected]{background-color:#3875d7;color:#fff}.select2-container--classic .select2-results__group{cursor:default;display:block;padding:6px}.select2-container--classic.select2-container--open .select2-dropdown{border-color:#5897fb}{"id":3981,"date":"2024-03-12T15:15:30","date_gmt":"2024-03-12T15:15:30","guid":{"rendered":"https:\/\/onlfr2023.excelentacj.ro\/?p=3981"},"modified":"2024-05-16T15:33:18","modified_gmt":"2024-05-16T15:33:18","slug":"instillazione-intrauterina-di-gonadotropina-4","status":"publish","type":"post","link":"https:\/\/onlfr2023.excelentacj.ro\/index.php\/2024\/03\/12\/instillazione-intrauterina-di-gonadotropina-4\/","title":{"rendered":"Instillazione intrauterina di gonadotropina corionica umana hCG prima del transfer di blastocisti Trial multicentrico"},"content":{"rendered":"
Tra le gonadotropine pi\u00f9 note ci sono l\u2019ormone follicolo stimolante (Fsh) e Lh (ormone luteinizzante). Questi ormoni sono attivi sia nelle ovaie sia nei testicoli e vengono prodotti dall\u2019ipofisi anteriore (adenoipofisi), la cui attivit\u00e0, a sua volta, \u00e8 controllata dall\u2019ipotalamo. Fsh e Lh, dopo essere stati secreti, vengono rilasciati nel sangue affinch\u00e9 si dirigano verso le cellule bersaglio per attivare diversi processi metabolici a seconda dell\u2019organo coinvolto. Il test della gonadotropina corionica umana (hCG), spesso chiamata beta-hCG (\u03b2hCG), misura la quantit\u00e0 di hCG presente nel sangue. Pu\u00f2 essere un utile sostegno alla diagnosi di malattia trofoblastica gestazionale (GTT) o, insieme alla misura dell\u2019AFP e della lattico deidrogenasi, dei tumori a cellule germinali. Con la menopausa i livelli degli ormoni follicolostimolante e luteinizzante subiscono un considerevole aumento (pari a 20 volte per il primo e a 3-5 volte per il secondo), in conseguenza della cessata produzione di estradiolo da parte dell\u2019ovaio, la cui riserva follicolare si \u00e8 ormai esaurita.<\/p>\n
Il trofoblasto comincia a produrre hCG poco dopo l\u2019annidamento dell\u2019embrione nella mucosa dell\u2019utero ed \u00e8 possibile rilevare la presenza dell\u2019ormone nelle urine e nel sangue materno gi\u00e0 a partire dalla seconda settimana dopo il concepimento. La sigla HCG che viene utilizzata per indicare la gonadotropina corionica umana deriva dall’inglese „Human Chorionic Gonadotropin” e, talvolta, viene utilizzato il sinonimo coriogonadotropina umana. Stimola la produzione di testosterone da parte delle cellule interstiziali del testicolo (dette cellule di Leydig). Per questo motivo, nel maschio, l’ormone luteinizzante assume il nome ICSH (acronimo di Interstitial Cell Stimulating Hormone).<\/p>\n
\u201cDonini nel secondo dopoguerra, \u00e8 il primo che intuisce che \u00e8 possibile utilizzare prodotti estratti dalle urine per avere a disposizione ormoni, che possono aiutare le donne a generare anche quando questo non era possibile a causa di una carenza di tipo ormonale\u201d commenta Sironi. TIPO DI CAMPIONEUn campione di urine del primo mitto del mattino o un campione di sangue ottenuto con un prelievo venoso. Quando le concentrazioni di hCG non tornano a livelli non determinabili, potrebbero indicare la presenza di tessuto secernente hCG che necessita di essere rimosso.<\/p>\n